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- 2023
- Audas Lab links the aggregation of pathological amyloids to a novel stress signaling pathway in recent Scientific Reports paper
- Beh lab shows how lipids regulate intracellular membrane contact in Journal of Biological Chemistry paper
- Congratulations to David Vocadlo: 2023 Distinguished SFU Professor
- Congratulations to Amy Lee: recipient of the 2023 Early Career Faculty Research Awards
- ILLUMINATING VIRAL PROTEIN SHEDS NEW LIGHT ON TREATMENT
- MBB researcher studying against the grain strategy to improve cancer treatment
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
- SFU research aids fight against treatment-resistant superbugs
- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
- Global News BC: Dr. Fiona Brinkman Discusses How Scientists Track Mutations in the New Covid-19 Variants
- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
- Congratulations to our June 2022 Graduands
- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
- Congratulations to our May 2022 Graduands
- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
- A New Paper from Beh Lab on ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways has been published in Plos Genetics Journal
- Dr. Lorena Braid is featured among new and renewed Canada Research Chairs
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Vocadlo Lab
We create new chemical and biochemical probes of glycan processing enzymes and use these to evaluate the roles of interesting glycoconjugates in cellular processes and diseases.
Cells from all domains of life are coated in glycans that are composed of distinct carbohydrate building blocks. The interdisciplinary laboratory of chemical glycobiology works at this frontier area of molecular biology to explore the functional roles of glycans in cell and organismal physiology. As part of this effort we study; (i) carbohydrate processing enzymes that act on glycans, (ii) develop chemical and biochemical tools to both perturb the action of these enzymes as well as to monitor glycans, and (iii) the use of these chemical tools to gain new understanding of how these glycans regulate cellular and organismal physiology. Members of the laboratory work as a team to address new problems in the area of glycobiology and come from different backgrounds including, for example, chemistry, biochemistry, and cell biology.
For more details, visit our research lab website.
Selected Publications
- Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ*, Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway. ACS Chemical Neuroscience 2018, 9, 1366-1379.
- Liu T-W, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ* Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila. Nature Chemical Biology, 2017, 13, 161-7.
- Cecioni S, Vocadlo DJ.* Carbohydrate bis-acetal-based substrates as tunable fluorescence-quenched probes for monitoring exo-glycosidase activity. Journal of the American Chemical Society 2017, 139, 8392-8395.
- Zhu, Y., Liu, T., Madden Z., Yuzwa, S.A., Murray, K., Cecioni, S., Zachara, N., Vocadlo, D.J.* Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter. Journal of Molecular Cell Biology 2016, 2-16.
- Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ.* O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nature Chemical Biology, 2015, 11, 319-25.