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Cells & Disease
Molecular genetic approaches are applied to the cell and developmental biology of model systems in order to understand how cells work in health and disease. Our interests include signal transduction, cilia, morphogenesis, cell death and autophagy, cytoskeleton, gene expression, cell division and polarity. Disease targets include cancer, cardiomyopathies, ciliopathies, neurodegenerative and inflammatory diseases.
Audas Lab
Understanding the role of noncoding RNA in the reversible formation of amyloid aggregates.
Beh Lab
In our laboratory, we exploit molecular genetics, biochemistry, and genomics to understand how the cell coordinates the transfer of molecular cargo between internal membranes to regulate its growth.
Braid Lab
Our laboratory explores the identity, function, and regulation of mesenchymal stem cells (MSCs) at the interface of immunity and regeneration. Our research examines how MSCs in various stem cell and perivascular niches contribute to tissue maintenance and regeneration. We also study how MSCs evolve over a lifetime of exposure to environmental stressors, becoming potential drivers of idiopathic and autoimmune diseases.
Gorski Lab
The study of autophagy (= “self-eating”) has generated tremendous attention due to the recognition that autophagy is involved in multiple developmental processes and human diseases including cancer.
EMAIL:
SHARON GORSKI
sgorski@bcgsc.ca
LAB ROOM:
Genome Sciences Centre at BC Cancer 7-124
LAB PHONE:
(604) 675-8000 (local 7905)
Hawkins Lab
The Hawkins lab uses C. elegans to investigate the molecular mechanisms underlying asymmetric cell division.
Holt Lab
The main focus in our lab (located at the BC Cancer Research Institute) is understanding and potentiating the anti-cancer immune response.
Jaumouillé Lab
Our laboratory use quantitative microscopy approaches to study the role of mechanical forces, cytoskeleton and membrane dynamics in the innate immune response to microbial infections and cancer.
Julian Lab
The Julian lab uses human pluripotent stem cells, organoid technologies, and cell biology and biochemical approaches to understand how neural stem cells build the brain and how disease-causing gene mutations disrupt these processes. Our goals are to uncover cellular mechanisms that can be targeted for disease treatment and to promote brain regeneration.
Leroux Lab
Our studies focus on the identification and cellular analysis of proteins found within cilia, the microtubule-based organelles implicated in an ever-growing number of human disorders (ciliopathies) that affect development and virtually all physiological functions.
Quarmby Lab
Summertime blooms of microalgae on snow cause "watermelon snow." We use the tools of genomics, bioinformatics, ecology and cell biology to study the algae, fungi, bacteria and other organisms comprising the the snow algae microbiome.
Setiaputra Lab
Our lab seeks to understand the molecular mechanisms underlying the mammalian DNA damage response. We are driven by our desire to better understand this fundamental aspect of our biology as well as the potential to manipulate DNA repair processes in genotoxic cancer therapy and gene editing.
Silverman Lab
We are cellular neurobiologists studying the role of protein transport in healthy and diseased neurons.
Tibbits Lab
Our research focuses on understanding the mechanisms of inherited cardiomyopathies and arrythmias. The SFU-based lab in TASC II focuses on the use of zebrafish and human recombinant protein structures that make up the thin filament of the cardiac contractile apparatus.
Verheyen Lab
The Verheyen lab uses developmental genetics, cell biology and biochemistry to understand how organs and tissues form and grow properly to shed light on normal development and human disease.
Vocadlo Lab
We create new chemical and biochemical probes of glycan processing enzymes and use these to evaluate the roles of interesting glycoconjugates in cellular processes and diseases.