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Lisa Craig
Department Chair, Professor
Molecular Biology & Biochemistry
Science
Areas of interest
We are interested in understanding the molecular mechanisms underpinning bacterial virulence. How do bacteria assemble and secrete virulence factors that allow them to colonise a host and cause disease? We apply x-ray crystallography, electron microscopy and genetic analysis to obtain atomic level structure/function information on molecules and molecular machines that impart virulence on bacterial pathogens. This information will guide the development of antimicrobial therapies aimed to disarm rather than kill bacteria in order to minimize antibiotic resistance.
Education
- B.Sc., University of British Columbia
- M.Sc., Simon Fraser University
- Ph.D., Simon Fraser University
Selected Publications
- M. Nguyen, T.-H. Wu, K.J. Danielson, N.M. Khan, Z. Zhan* and L. Craig. Mechanism of secretion of TcpF by the Vibrio cholerae toxin coregulated pilus. Proc Nat’l Acad Sci, DOI: 10.1073/pnas.2212664120, PMID 27040409, 2023. https://www.pnas.org/doi/10.1073/pnas.2109364118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
- J.L. Chlebek, R. Denise, L. Craig and A.B. Dalia (2021). Motor-independent retraction of type IV pili is governed by an inherent property of the pilus filament. Proc Natl Acad Sci 118, DOI: 10.1073/pnas.2102780118, PMID 34789573. https://www.pnas.org/doi/10.1073/pnas.2102780118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
- J.-P. Barnier, J. Meyer, S. Kolappan, B. Bouzinba-Ségard, G. Gesbert, A. Jamet, E. Frapy, S. Schönherr-Hellec, E. Capel, Z. Virion, M. Dupuis, E. Bille, P. Morand, T. Schmitt, S. Bourdoulous, X. Nassif, L. Craig* and M. Coureuil* (2021). The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus. Proc Natl Acad Sci 118, DOI: 10.1073/pnas.2109364118, PMID 34725157. https://www.pnas.org/doi/10.1073/pnas.2109364118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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Important Notice
Research Technician Position Available
Courses
Spring 2024
Future courses may be subject to change.