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- 2023
- Audas Lab links the aggregation of pathological amyloids to a novel stress signaling pathway in recent Scientific Reports paper
- Beh lab shows how lipids regulate intracellular membrane contact in Journal of Biological Chemistry paper
- Congratulations to David Vocadlo: 2023 Distinguished SFU Professor
- Congratulations to Amy Lee: recipient of the 2023 Early Career Faculty Research Awards
- ILLUMINATING VIRAL PROTEIN SHEDS NEW LIGHT ON TREATMENT
- MBB researcher studying against the grain strategy to improve cancer treatment
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
- SFU research aids fight against treatment-resistant superbugs
- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
- Global News BC: Dr. Fiona Brinkman Discusses How Scientists Track Mutations in the New Covid-19 Variants
- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
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- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
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- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
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Holt Lab
The main focus in our lab (located at the BC Cancer Research Institute) is understanding and potentiating the anti-cancer immune response.
Increasingly cancer is being seen as a disease of immune failure, and in the field considerable effort is being focused on evoking and/or potentiating anti-tumor immunity. In our group, we do basic research, pre-clinical research and clinical (Phase I/II) studies focussed on genetically enginerring T cells to target cancer cells. We also develop mRNA vaccines against "Oncomicrobes and we use high-throughput genomic, proteomic and bioinformatic methods to probe the cellular immune system, with a focus on antigen discovery. In addition to immunology, we also touch on aspects of microbiome research, brain research and evolutionary biology in our group
For more details on current research projects, visit our research lab website.
Selected Publications
- Rive CM, Yung E, Dreolini L, Woodsworth DJ, Holt RA. Selective B cell depletion upon infusion of replication-incompetent anti-CD19 CAR lentivirus. BioRxiv.
- Rive CM, Yung E, Hughes CS, Brown SD, Sharma G, Dreolini L, Warren C, Karasinska JM, Loree JM, Yapp DT, Morin GB, Renouf DJ, Schaeffer DF, Turcotte S and Holt RA. Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations. BioRxiv.
- Cochrane K, Robinson AV, Holt RA, Allen-Vercoe E. A survey of Fusobacterium nucleatum genes modulated by host cell infection. Microbial Genomics. 2020 Feb;6(2):e000300. doi: 10.1099/mgen.0.000300.. PMID: 31661053
- Sharma G, Rive C and Holt RA. Rapid selection and identification of functional CD8+ T-cell epitopes from large peptide coding libraries. Nature Communications. 2019 Oct 7;10(1):4553. doi: 10.1038/s41467-019-12444-7. PMID: 31591401
- Holt RA. Immunogenomics: a foundation for intelligent immune design.Genome Medicine. 2015;7:116. doi:10.1186/s13073-015-0247-y. Read more.