- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Lisa Julian
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Lynne Quarmby
- Dheva Setiaputra
- Michael Silverman
- Sophie Sneddon
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Admission & Transferring
- Degree Programs
- MBB Co-op Program
- Careers in Molecular Biology and Biochemistry
- Scholarships & Funding
- Student Stories
- Contact Us
- Current Students
- Advising
- Courses
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Prospective Students
- Graduate
- Graduate Studies Overview and Timeline
- Prospective Students
- Current Students
- Manage Your Program
- Degree Requirements
- Courses
- Course Descriptions
- Course Offerings
- Spring (1251)
- Summer (1254)
- Spring (1241)
- Summer (1244)
- Fall (1247)
- Spring (1231)
- Summer (1234)
- Fall (1237)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Spring (1151)
- Graduate Student Stipend & Awards
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig Lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao Lab
- Jaumouillé Lab
- Julian Lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Setiaputra Lab
- Silverman Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young Lab
- Bioinformatics & Genomics
- Cells & Disease
- Infection & Immunity
- Macromolecular Biochemistry
- Undergraduate Research Opportunities
- Postdoctoral Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Recent Publications
- Research Labs
- Resources
- News & Events
- Support MBB
- Faculty + Staff Portal
Leroux Lab
The focus of our studies is to identify and characterise proteins found within the cilium, an evolutionarily ancient microtubule-based organelle found on virtually all human cells.
Using the nematode C. elegans, we study intraflagellar transport, a kinesin- and dynein-dependent transport process necessary to form and maintain the complex ciliary structure. We also aim to understand the makeup and function of the transition zone, a ‘gate’ that controls ciliary composition and thus function. Importantly, our biomedical research probes the molecular basis of several human disorders arising from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. Such ‘ciliopathies’ are characterised by a wide range of ailments, such as obesity, kidney and heart anomalies, blindness, skeletal malformations, and neurosensory impairment.
For more information, visit our research lab website.
Selected Publications
- Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J; Genomics England Research Consortium; Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, Leroux MR. The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision. Nat Commun, 2022
- Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol, 2017
- Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 2018
- Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol, 2016
- View more publications