- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jack Chen
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Frederic Pio
- Lynne Quarmby
- Dheva Setiaputra
- Sophie Sneddon
- Jenifer Thewalt
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Current Students
- Advising
- Courses
- Course Offerings
- Summer (1234)
- Spring (1231)
- Fall (1227)
- Summer (1224)
- Spring (1221)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Fall (1237)
- Course Descriptions
- Course Offerings
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Graduate
- Prospective Students
- Current Students
- Manage Your Program
- Courses
- Course Descriptions
- Course Offerings
- Spring (1231)
- Summer (1234)
- Fall (1237)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao lab
- Jaumouillé lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Setiaputra Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young lab
- Bioinformatics & Genomics
- Cells & Disease
- Infection & Immunity
- Macromolecular Biochemistry
- Undergraduate Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Research Labs
- Resources
- News & Events
- Support MBB
- Faculty + Staff Portal
Leroux Lab
The focus of our studies is to identify and characterise proteins found within the cilium, an evolutionarily ancient microtubule-based organelle found on virtually all human cells.
Using the nematode C. elegans, we study intraflagellar transport, a kinesin- and dynein-dependent transport process necessary to form and maintain the complex ciliary structure. We also aim to understand the makeup and function of the transition zone, a ‘gate’ that controls ciliary composition and thus function. Importantly, our biomedical research probes the molecular basis of several human disorders arising from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. Such ‘ciliopathies’ are characterised by a wide range of ailments, such as obesity, kidney and heart anomalies, blindness, skeletal malformations, and neurosensory impairment.
For more information, visit our research lab website.
Email:
MICHEL LEROUX
leroux@sfu.ca
Lab Room:
SSB 6144
Lab Phone:
(778) 782-5785
Selected Publications
- Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE, Leroux MR. CDKL kinase regulates the length of the ciliary proximal segment. Curr Biol, 2021
- Loucks CM, Park K, Walker DS, McEwan AH, Timbers TA, Ardiel EL, Grundy LJ, Li C, Johnson JL, Kennedy J, Blacque OE, Schafer W, Rankin CH, Leroux MR. EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling. Elife, 2019
- Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 2018
- Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol, 2017
- Jensen VL, Carter S, Sanders AA, Li C, Kennedy J, Timbers TA, Cai J, Scheidel N, Kennedy BN, Morin RD, Leroux MR, Blacque OE. Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport. PLoS Genet, 2016