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Larijani Lab
We are interested in genome-mutating processes.
Selected Publications
- King JJ, Borzooee, F, Im J, Asgharpour M, Ghorbani A, Diamond CP, Fifield H, Berghuis L, Larijani M. Structure-based design of first-generation small molecule inhibitors targeting the catalytic pockets of AID, APOBEC3A and APOBEC3B. ACS Pharmacology & Translational Science. 2021. ACS Pharmacol Transl Sci. 2021 Jul 19;4(4):1390-1407 (selected for cover figure)
- Ghorbani A, Quinlan EM, Larijani M. Evolutionary comparative analyses of DNA-editing enzymes of the immune system: from 5-dimensional description of protein structures to immunological insights and applications to protein engineering. Frontiers in Immunology. 2021. May 31;12:642343.
- King JJ, Larijani M. Structural plasticity of substrate selection by activation-induced cytidine deaminase as a regulator of its genome-wide mutagenic activity. FEBS Letters. 2020. 595(1):3-13 (selected for cover figure)
- Branton SA, Ghorbani A, Bolt BN, Fifield H, Berghuis LM, Larijani M. Activation-induced cytidine deaminase can target multiple topologies of double-stranded DNA in a transcription-independent manner. FASEB J. 2020. Jul;34(7):9245-9268
- Holland SJ, Berghuis LM, King JJ, Iyer L, Sikora K, Fifield H, Peter S, Quinlan EM, Fumiaki S, Prashant S, Trancoso I, Iwanami N, Temereva E, Strohmeier C, Kuratani S, Venkatesh B, Evanno G, Aravind L, Schorpp M, Larijani M*, Boehm T*. Expansions, diversification and inter-individual copy number variation of AID/APOBEC family cytidine deaminase genes in lampreys. Proc Natl Acad Sci, 2018. Mar 19. pii: 201720871 (*ML and TB co-senior authors)
- Borzooee F, Asgharpour M., Quinlan E., Grant M., Larijani M. Viral subversion of APOBEC3s: lessons for anti-tumor immunity and tumor immunotherapy. International Rev. Immunol. 2017. Dec 6:1-14. doi: 10.1080/08830185
- Quinlan EM, King JJ, Amemiya CT, Hsu E, Larijani M. Biochemical regulatory features of AID have remained conserved from lamprey to humans. Mol Cell. Biol. 2017. Jul 17. pii: MCB.00077-17
- King JJ, Larijani M. A novel regulator of AID/APOBECs: Schrödinger's CATalytic pocket, Frontiers Imm. 2017, Apr 6;8:351
- King JJ, Manuel CA, Barrett CV, Raber S, Lucas HM, Sutter P, Larijani M. Catalytic pocket inaccessibility of activation induced cytidine deaminases a safeguard against excessive mutagenic activity, Structure. 2015. Apr 7; 23(4):615-27