- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jack Chen
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Frederic Pio
- Lynne Quarmby
- Sophie Sneddon
- Jenifer Thewalt
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Current Students
- Advising
- Courses
- Course Offerings
- Summer (1234)
- Spring (1231)
- Fall (1227)
- Summer (1224)
- Spring (1221)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Course Descriptions
- Course Offerings
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Graduate
- Prospective Students
- Current Students
- Manage Your Program
- Courses
- Course Descriptions
- Course Offerings
- Spring (1231)
- Summer (1234)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao lab
- Jaumouillé lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young lab
- Undergraduate Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Research Labs
- Resources
- News & Events
- MBB Calendar
- Colloquia
- Honours & Awards
- News Archives
- 2023
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
- SFU research aids fight against treatment-resistant superbugs
- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
- Global News BC: Dr. Fiona Brinkman Discusses How Scientists Track Mutations in the New Covid-19 Variants
- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
- Congratulations to our June 2022 Graduands
- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
- Congratulations to our May 2022 Graduands
- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
- A New Paper from Beh Lab on ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways has been published in Plos Genetics Journal
- Dr. Lorena Braid is featured among new and renewed Canada Research Chairs
- 2021
- 2020
- 2019
- 2018
- 2017
- 2016
- 2015
- 2023
- Support
- Faculty + Staff Portal
Braid lab
A translational research program focused on developing next-generation cell therapies by characterizing the elusive identity and function of mesenchymal stem and stromal cells (MSC) in physiological maintenance and regeneration, their evolution in response to stressors, and their role in auto-immune disease and wound healing.
The Braid MSC Discovery and Innovation Lab is working to design the next generation of mesenchymal stem and stromal cell (MSCs) therapies. Through strategic partnerships across disciplines, government, industry and academia, we are also developing new technologies to fill current gaps in MSC manufacturing and release testing and ease-of-administration to better enable clinical adoption and regulatory approval of MSC therapies worldwide.
Our research program focuses on the enigmatic and functionally profound mesenchymal stem and stromal cell (MSC) populations. Our team characterizes the transcriptional, molecular, metabolic and functional phenotypes of tissue-resident and culture expanded human MSCs using cellomics (high content and live cell imaging), next-generation sequencing and metabolomics. Our aim is to understand how MSCs respond, adapt and evolve in response to environmental and pathogenic stresses, and to identify new markers of MSC subpopulations. We use this information to generate new research tools and technologies to study endogenous MSCs, to model MSC interactions in physiological and pathological states, to develop biomarkers and functional assays to support clinical translation of consistent (batch-to-batch) and efficacious MSC products, and to discover next generation therapeutics that rejuvenate or eliminate tissue-resident MSCs that may underlie auto-immune and aging-related diseases.
Email:
LORENA BRAID
lrbraid@sfu.ca
Assistant Professor
Canada Research Chair in Mesenchymal Stromal Cell Biology, Tier 2
Office: SSB 7152
Office phone: 778-782-3459
Lab Room: SSB 6150
Lab phone: 778-782-5879
Selected Publications
- Wiese, D.W., Wood, C.A. and Braid, L.R. (2022). From Vial to Vein: Crucial Gaps in Mesenchymal Stromal Cell Clinical Trial Reporting. Frontiers in Cell and Developmental Biology, Stem Cell Research, research topic "Mesenchymal Stromal Cells: Preclinical and Clinical Challenges". In Press
- Wiese and Braid (2020). Transcriptome profiles acquired during cell expansion and licensing validate mesenchymal stromal cell lineage genes. Stem Cell Research & Therapy. 11:357.
- Braid et al. (2019). Human umbilical cord perivascular cells: a novel source of the organophosphate antidote butyrylcholinesterase. Chemico-Biological Interactions. (305) 66-78.
- Wiese et al. (2019). Accumulating transcriptome drift precedes cell aging in human umbilical cord-derived mesenchymal stromal cells serially cultured to replicative senescence. Stem Cells TranslationalMedicine. (08) 945-958.
- Braid et al. (2018). Intramuscular administration potentiates extended dwell time of mesenchymal stromal cells compared to other routes. Cytotherapy (20) 232-244.
- Braid et al. (2016). Engineered mesenchymal cells improve passive immune protection against lethal exposure to Venezuelan equine encephalitis virus exposure. Stem Cells Translational Medicine (5) 1-10
Courses
Fall 2023
Future courses may be subject to change.