Sharon Gorski

Areas of interest

Autophagy is an intracellular recycling process that promotes stress adaptation and cell survival. Our research program explores the contributions of autophagy to proteostasis, normal development, and cancer progression with a focus on breast and pancreatic cancers. We are also investigating the therapeutic potential of autophagy modulation in these cancers.

Education

B.Sc., Biology (honours), Simon Fraser University
M.Sc., Genetics, University of British Columbia
Ph.D., Developmental Biology, Washington University School of Medicine, St. Louis, USA

Selected Publications

Bosc D, Vezenkov L, Bortnik S, An J, Xu J, Choutka C, Hannigan AM, Kovacic S, Loo S, Clark PGK, Chen G, Guay-Ross RN, Yang K, Dragowska WH, Zhang F, Go NE, Leung A, Honson NS, Pfeifer TA, Gleave M, Bally M, Jones SJ, Gorski SM, Young RN. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Scientific Reports. 2018; 8(1):11653. PMID: 30076329
Xu J, Camfield R, Gorski SM. The interplay between exosomes and autophagy - partners in crime. Journal of Cell Science. 2018; 131(15). PMID: 30076239
Choutka C, DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM. Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy. Autophagy. 2017; 13(9):1573-1589. PMID: 28806103
Bortnik S, Choutka C, Horlings HM, Leung S, Baker JH, Lebovitz C, Dragowska WH, Go NE, Bally MB, Minchinton AI, Gelmon KA, Gorski SM. Identification of breast cancer cell subtypes sensitive to ATG4B inhibition. Oncotarget. 2016; 7(41):66970-66988. PMID: 27556700
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Courses

Fall 2023

Spring 2024

Future courses may be subject to change.

Department of Molecular Biology and Biochemistry

Sharon M. Gorski