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- 2023
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
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- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
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- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
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Mark Brockman
Professor
Health Sciences
Areas of interest
The research in our laboratory uses molecular and cell biology methods to investigate key questions at the interface of virology, pathogenesis, and the human cellular immune response to human immunodeficiency virus (HIV) infection. Ongoing studies aim to understand the impact of viral immune escape mutations on HIV protein function and cytotoxic T lymphocyte (CTL) recognition, to assess the role of HIV accessory proteins in establishment and maintenance of viral latency, and to employ new assays to identify patient-derived T cell receptors (TCR) that display enhanced ability to recognize HIV-infected cells.
Education
- B.A., Beloit College
- Ph.D., Harvard University
Selected Publications
- Ogunshola, Anmole, et al. (2018) Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV Gag escape variants. Nature Communications (Accepted)
- Alsahafi et al. (2017) Impaired downregulation of NKG2D ligands by Nef protein from elite controllers sensitize HIV-1-infected cells to ADCC. Journal of Virology 91(16):e00109-17. doi: 10.1128/JVI.00109-17
- Mwimanzi et al. (2016) Novel acylguanidine-based inhibitor of HIV-1. Journal of Virology 90(20):9495-508. doi: 10.1128/JVI.01107-16
- View more publications
Courses
Fall 2023
Future courses may be subject to change.