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Mark Paetzel
Professor
Molecular Biology & Biochemistry
Science
Areas of interest
Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.
Education
- A.A. (Theology), Golden Valley Lutheran College
- B.Sc. (Biology), Syracuse University
- B.Sc. (Chemistry), University of Minnesota
- Ph.D. (Chemistry), Ohio State University
Selected Publications
- Lee, J. et al. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications 2022
- Lee et al. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nature Communications 2020
- Paetzel, M. Bacterial Signal Peptidases. Subcellular Biochemistry 2019
- View more publications
Important Notice
MSc and PhD Student Positions Available – THE NATURE OF BIOMOLECULES
The Paetzel lab currently has openings for MSc or PhD students.
Thesis projects are designed to suit your interests and strengths and vary from chemical to computational, from pathogen to host, and from basic research to applied research.
Please visit the lab website to learn more and e-mail Dr. Paetzel (mpaetzel@sfu.ca) with transcripts and CV.
Courses
Fall 2023
Future courses may be subject to change.