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Mark Paetzel
Professor
Molecular Biology & Biochemistry
Science
Areas of interest
Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.
Education
- A.A. (Theology), Golden Valley Lutheran College
- B.Sc. (Biology), Syracuse University
- B.Sc. (Chemistry), University of Minnesota
- Ph.D. (Chemistry), Ohio State University
Selected Publications
- Lee, J. et al. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications 2022
- Lee et al. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nature Communications 2020
- Paetzel, M. Bacterial Signal Peptidases. Subcellular Biochemistry 2019
- View more publications
Important Notice
MSc Student – Structure and Function of Viral Proteases
The Paetzel lab currently has an opening for a MSc student. The thesis project will involve the structural and mechanistic analysis of viral proteases. Please visit the lab website (LINK: http://www.sfu.ca/~mpaetzel/) to learn more and e-mail Dr. Paetzel (mpaetzel@sfu.ca) with transcripts and CV.
Courses
Summer 2023
Future courses may be subject to change.