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Mark Paetzel
Professor
Molecular Biology & Biochemistry
Science
Areas of interest
Our lab uses molecular biology, protein chemistry, X-ray crystallography and other physical methods to investigate the structure and catalytic mechanism of enzymes. Currently we have many project related to viral protease self-processing, compartmentalized proteases, and eukaryotic membrane bound proteases.
Education
- A.A. (Theology), Golden Valley Lutheran College
- B.Sc. (Biology), Syracuse University
- B.Sc. (Chemistry), University of Minnesota
- Ph.D. (Chemistry), Ohio State University
Selected Publications
- Luo and Paetzel Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2. Journal of Structural Biology 2025
- Lee, J. et al. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications 2022
- Lee et al. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nature Communications 2020
- View more publications
Important Notice
MSc Student Positions Available – STRUCTURE AND SENSORS
The Paetzel lab currently has openings for MSc students.
Thesis projects will relate to protease structure and mechanism or biosensor development.
Please visit the lab website to learn more and e-mail Dr. Paetzel (mpaetzel@sfu.ca) with transcripts and CV.
Courses
This instructor is currently not teaching any courses.