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- 2023
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
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Brockman Lab
Our research uses molecular, cell biology and single-cell transcriptomics approaches to investigate viral pathogenesis and the human cellular immune response to infection.
Our research uses molecular, cell biology and single-cell transcriptomics approaches to investigate viral pathogenesis and the human cellular immune response to infection.
Viruses constantly evolve and adapt to their hosts. By incorporating methods from the fields of virology and immunology, our lab examines host-virus interactions that contribute to pathogenesis and disease. We are particularly interested to understand mechanisms of cell-mediated immune control of infection and how viruses attempt to evade them. Current projects investigate the human immune response to HIV and SARS-CoV-2; examine the impact of viral mutations on immune recognition and protein function; and assess the immune evasion properties of viral accessory proteins. Our lab is also actively engaged in national and international research and training collaborations, including ongoing support for Canada’s response to COVID-19 and global efforts to develop an effective vaccine or cure for HIV.
For more information, visit our research lab website.
Email:
MARK BROCKMAN
mark_brockman@sfu.ca
Lab Room:
TASC II 8130; BLU 9865; BLU 11750
Lab Phone:
(778) 782-8889
Selected Publications
- Bansal A et al. (2021) HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection. Journal of Clinical Investigation. 131(16):e148979 doi: 10.1172/JCI148979
- Jin SW et al. (2020) Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. PLoS Pathogens 16(9):e1008813. doi: 10.1371/journal.ppat.1008813.
- Umviligihozo G et al. (2020) Differential Vpu-mediated CD4 and tetherin downregulation function among major HIV-1 group M subtypes. Journal of Virology 94(14):e00293-20. doi: 10.1128/JVI.00293-20.
- Ogunshola F, Anmole G et al. (2018) Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV Gag escape variants. Nature Communications 9:5023. doi: 10.1038/s41467-018-07209-7