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Brockman Lab
Our research uses molecular, cell biology and single-cell transcriptomics approaches to investigate viral pathogenesis and the human cellular immune response to infection.
Our research uses molecular, cell biology and single-cell transcriptomics approaches to investigate viral pathogenesis and the human cellular immune response to infection.
Viruses constantly evolve and adapt to their hosts. By incorporating methods from the fields of virology and immunology, our lab examines host-virus interactions that contribute to pathogenesis and disease. We are particularly interested to understand mechanisms of cell-mediated immune control of infection and how viruses attempt to evade them. Current projects investigate the human immune response to HIV and SARS-CoV-2; examine the impact of viral mutations on immune recognition and protein function; and assess the immune evasion properties of viral accessory proteins. Our lab is also actively engaged in national and international research and training collaborations, including ongoing support for Canada’s response to COVID-19 and global efforts to develop an effective vaccine or cure for HIV.
For more information, visit our research lab website.
Email:
MARK BROCKMAN
mark_brockman@sfu.ca
Lab Room:
TASC2 8130
BLU 9865
BLU 11750
Lab Phone:
(778) 782-8889
Selected Publications
- Datwani S, Kalikawe R, et al. (2023) Dynamics of T-cell Responses Following COVID-19 mRNA Vaccination and Breakthrough Infection in Older Adults. Pathogens and Immunity. 8(1):117-135. doi: 10.20411/pai.v8i1.613.
- Mwimanzi F, et al. (2023) Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine. Open Forum Infectious Diseases. 10(3):ofad073. doi: 10.1093/ofid/ofad073.
- Umviligihozo G, et al. (2022) Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors. Frontiers in Virology. 2:917902. doi: 10.3389/fviro.2022.917902.
- Bansal A, et al. (2021). HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection. Journal of Clinical Investigation. 16;131(16). doi: 10.1172/JCI148979.
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