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Recent Publications

2026

Rapid early life colonization of the intestinal tract by Akkermansia muciniphila after voluntary feeding
Dumlao JM, McCallum P, Hodak CR, Guinto E, Enns W, Davey LE, Choy JC. BMC Microbiology. 2026 May 23.

HNRNPU Mutations Redirect Cell Cycle Control to E2F in MYC-Driven Lymphomas
Qureshi Q, Coyle KM, Brown C, Thomas N, Collinge B, Dreval K, Steidl C, Scott DW, Audas TE, Morin RD. Blood Advances. 2026 May 12:bloodadvances.2025019135

An animal component-free bioprocess for synthesizing 3D human matrix scaffolds using mesenchymal stromal cells
Stein SN, Braid LR. Frontiers in Cell and Developmental Biology. 2026 Apr 13;14:1624745.

A gene-editing method generates immunotherapeutic CAR T cells in the body
Holt R, Evgin L. Nature. 2026 Apr;652(8110):572-574. 

Pharmacological inhibition ofO-GlcNAcase reduces pS129-α-synucleinpositive aggregates in the substantianigra of mThy1-hSNCA mice
Yue J, Jones B, Tran KH, Deen M, Holicek V, Cheng WH, Michalik M, Power S, Wellington CL, Watson NV, Vocadlo DJ. Journal of Parkinsons Disease. 2026 Mar;16(2):217-232.

Uncovering functional insights into human pathogenic variants in CDK19 using Drosophila models
Grewal KS, Tam C, Liao JZ, Verheyen EM. Human Molecular Genetics. 2026 Feb 8;35(1):ddaf174.

Self-Multimerization of mRNA LNP-Derived Antigen Improves Antibody Responses
Despins, CA, Round, J, Dreolini, L, Lee, TS, Brown, SD, & Holt, RA. Vaccines (Basel). 2026 Jan 12;14(1):80.

The Mpox contextual data specification package: a data curation toolkit to support collaborative pathogen genomic surveillance
Griffiths, EJ., Cameron, R, Barclay, C, John, NS, Dooley, D, ... Hsiao, WWL. Microbial Genomics. 2026 Jan;12(1).

2025

Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2
Chuanyun Luo and Mark Paetzel. Journal of Structural Biology, Volume 217, Issue 4, art. no. 108260

High-throughput bioprinting to produce micropatterned neuroepithelial tissues and model TSC2-deficient brain malformations
Imani Farahani, N., Wong, K.K.L., Allen, G., Minhas, A., Lin, L, Nazir, S., Julian, L.M. Cell Reports Methods, art. no. 101177.

VIRUS-MVP: a framework for comprehensive surveillance of viral mutations and their functional impacts
Anwar, M.Z., Gill, I.S., Iseminger, M.,, Gordon, P.M.K., Hsiao, W.W.L.,Nar Genomics and Bioinformatics, 7(4), art. no. lqaf132.

The genotypic characterization of Streptococcus pluranimalium from aborted bovine fetuses in British Columbia, Canada
Yee, M., Trimble, M.J., Ghosh, K., (...), McGregor, G., Hsiao, W.W.L., Frontiers in Microbiology, 16, art. no. 1603770.

Machine learning reveals the dynamic importance of accessory sequences for Salmonella outbreak clustering
Liu, C.C., Hsiao, W.W.L., mBio, 16(3), art. no. e02650-24

Biochemical assays for AID/APOBECs and the identification of AID/APOBEC inhibitors
Govindarajan, P., Zeng, Y., Larijani, M., Methods in Enzymology.

2024

Rosetta gen. nov. (Chlorophyta): Resolving the identity of red snow algal rosettes *Wiley Top Viewed Article 2025
Engstrom CB, Raymond BB, Albeitshawish J, Bogdanovic A, Quarmby LM. J Phycol. 2024 Apr;60(2):275-298.

Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar K
Lu X, Passalacqua LFM,  Nodwell M, Kong, KYS, Caballero-García, G, Dolgosheina, EV, Ferré-D’Amaré, AR, Britton, R, Unrau, PJ, Nucleic Acids Research, Volume 52, Issue 14

Regulation of yeast polarized exocytosis by phosphoinositide lipids
Volpiana MW, Nenadic A, Beh CT., Cellular and Molecular Life Sciences, 81(1), art. no. 457.

C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors
Barbelanne M, Lu Y, Kumar K, Zhang X, Li C, Park K, Warner A, Xu XZS, Shaham S, Leroux MR., Scientific Reports, 14(1), art. no. 28347.

Extracellular matrix of the nervous system
Nazir S, Feresten AH, Lin L, Hutter H, Julian LM,, Handbook of Neural Engineering: a Modern approach, Pages 97 - 1471.

Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Ging K, Frick L, Schlachetzki J, Armani A, Zhu Y, Gilormini PA, Dhingra A, Böck D, Marques A, Deen M, Chen X, Serdiuk T, Trevisan C, Sellitto S, Pisano C, Glass CK, Heutink P, Yin JA, Vocadlo DJ, Aguzzi A, npj Parkinson's Disease, 10(1), art. no. 192.

Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes
Maaref Y, Jannati S, Jayousi F, Lange P, Akbari M, Chiao M, Tibbits GF, Acta Biomaterialia. Volume 190, Pages 133 - 151.

Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation
An AY, Acton E, Idoko OT, Shannon CP, Blimkie TM, Falsafi R, Wariri O, Imam A, Dibbasey T, Bennike TB, Smolen KK, Diray-Arce J, Ben-Othman R, Montante S, Angelidou A, Odumade OA, Martino D, Tebbutt SJ, Levy O, Steen H, Kollmann TR, Kampmann B, Hancock REW, Lee AH, eBioMedicine. Volume 110 105411.

High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease
Williams D, Glasstetter LM, Jong TT, Chen T, Kapoor A, Zhu S, Zhu Y, Calvo R, Gehrlein A, Wong K, Hogan AN, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y, Proceedings of the National Academy of Sciences of the United States of America. 121(42).

The Canadian VirusSeq Data Portal and Duotang: open resources for SARS-CoV-2 viral sequences and genomic epidemiology
Gill EE, Jia B, Murall CL, Poujol R, Anwar MZ, John NS, ... Brinkman FSL. , Microbial genomics. 10(10).

Snow alga Sanguina aurantia as revealed through de novo genome assembly and annotation
Raymond BB, Guenzi-Tiberi P, Maréchal E, Quarmby LM, G3: Genes, Genomes, Genetics. 14(10). art. no. jkae181.

Whole-genome sequencing of Western Canadian Borrelia spp. collected from diverse tick and animal hosts reveals short-lived local genotypes interspersed with longer-lived continental genotypes
Russell JN, Lee MK, Uyaguari-Diaz MI, Sies AN, Suchan DM, Hsiao W, Fraser E, Morshed MG, Cameron ADS, Microbial genomics, 10(8).

Chromosome-scale genome assembly reveals insights into the evolution and ecology of the harmful algal bloom species Phaeocystis globosa Scherffel
Chen N, Xu Q, Zhu J, Song H, He L, Liu S, Song X, Yuan Y, Chen Y, Cao X, Yu Z, iScience, 27(8), art. no. 110575.

Whole-genome sequencing of Western Canadian Borrelia spp. collected from diverse tick and animal hosts reveals short-lived local genotypes interspersed with longer-lived continental genotypes
Russell JN, Lee MK, Uyaguari-Diaz MI, Sies AN, Suchan DM, Hsiao W, Fraser E, Morshed MG, Cameron ADS, Science of the Total Environment, 950, art. no. 175358.

Comparative assessment of the intragenomic variations of dinoflagellate Tripos species through single-cell sequencing
Huang X, Li Y, Du H, Chen N, Marine Pollution Bulletin, 206, art. no. 116690.

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Nickerson R, Thornton CS, Johnston B, Lee AHY, Cheng Z, Frontiers in Immunology, 15, art. no. 1405376.

A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies
Gilormini PA, Thota VN, Fers-Lidou A, ..., Britton R, Vocadlo DJ, Proceedings of the National Academy of Sciences of the United States of America, 121(27), art. no. e2314026121.

Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome
Tophkhane SS, Fu K, Verheyen EM, Richman JM., DMM Disease Models and Mechanisms, 17(6), art. no. dmm050584.

Last but not least: emerging roles of the autophagy-related protein ATG4D
McMann E, Gorski SM, Autophagy.