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- 2023
- Audas Lab links the aggregation of pathological amyloids to a novel stress signaling pathway in recent Scientific Reports paper
- Beh lab shows how lipids regulate intracellular membrane contact in Journal of Biological Chemistry paper
- Congratulations to David Vocadlo: 2023 Distinguished SFU Professor
- Congratulations to Amy Lee: recipient of the 2023 Early Career Faculty Research Awards
- ILLUMINATING VIRAL PROTEIN SHEDS NEW LIGHT ON TREATMENT
- MBB researcher studying against the grain strategy to improve cancer treatment
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
- SFU research aids fight against treatment-resistant superbugs
- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
- Global News BC: Dr. Fiona Brinkman Discusses How Scientists Track Mutations in the New Covid-19 Variants
- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
- Congratulations to our June 2022 Graduands
- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
- Congratulations to our May 2022 Graduands
- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
- A New Paper from Beh Lab on ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways has been published in Plos Genetics Journal
- Dr. Lorena Braid is featured among new and renewed Canada Research Chairs
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Areas of interest
My research interest is in understanding the molecular basis for antigen recognition by antibodies using peptide as probes of these interactions. My postdoctoral work involved the initial development of phage-displayed, peptide libraries for this purpose. A peptide library comprises tens of millions of short, variable, amino acid sequences that have been engineered into a viral coat protein, thereby displaying the fusion products on the surface of filamentous bacteriophage. The phage-displayed peptide is linked to an amplifiable readout, encoded on the viral genome. This allows a library to be searched with binding molecules such as antibodies, receptors and enzymes, using affinity-selection to find the rare phage displaying binding peptides. The sequences of binding peptides can be easily determined from clones isolated from affinity-enriched phage pools, by sequencing the region of phage DNA encoding the variable peptides.
As a molecular immunologist and physician, I have a strong interest in understanding how the peptide recognition profile of an antibody response may be applied to the development of vaccines and autoimmune diagnostics. One of our most interesting projects involves our search for peptides will bind to human monoclonal antibodies that kill HIV-1. We hope to create a vaccine that will elicit these same antibodies in uninfected people, and thus protect them from AIDS.
Education
- B.A. (Biological Sciences), Occidental College
- Ph.D. (Cellular & Molecular Biology), University of Missouri-Columbia
- M.D. Saint Louis University
Selected Publications
- Montero M, Gulzar N, Klaric KA, Donald JE, Lepik C, Wu S, Tsai S, Julien JP, Hessell AJ, Wang S, Lu S, Burton DR, Pai EF, Degrado WF, Scott JK., (2012) Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane. J. Virol. 86(6): 2930-2941.
- Breden, F, Lepik C, Longo NS, Montero M, Lipsky PE, Scott JK (2011) Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune disease. < http://www.ncbi.nlm.nih.gov/pubmed/21479208> PLoS One 6(3):316857 (11 pages)
- Watson CT, Steinberg KM, Huddleston J, Warren RL, Malig M, Schein J, Willsey AJ, Joy JB, Scott JK, Graves TA, Wilson RK, Holt RA, Eichler EE, Breden F. (2013) Am. J. Hum Genet. Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Copy-Number Variation. 92(4): 530-546.