Choy Lab

Immune responses that cause organ transplant rejection and autoimmune diseases

Research in my laboratory is focused on understanding how the immune system is activated towards transplanted organs and how it causes resultant rejection. We have provided particular attention to how innate immune signals, such as cytokines secreted by innate immune cells and vascular cells, control the activation of T cells and how the gut microbiota influences immune responses that cause organ transplant rejection.  Studies are also investigating cell engineering approaches that protect blood vessels in transplanted organs and how this can be applied to prevent rejection.

Nitric oxide signaling and production

Nitric oxide (NO) is a bioactive gas that controls many cell biological responses. Dysregulation of its production and/or bioactivity is involved in many diseases. My laboratory is interested in understanding how NO effects cell signaling and how its production is controlled by NO synthases. The role of NO and NO synthases in cell biology and immune responses is also being studied.

Email: 

JONATHAN CHOY
jonathan_choy@sfu.ca

LAB ROOM: 

TASC II 8130 

LAB PHONE:

(778) 782-8707