- About
- People
- Faculty
- Tim Audas
- Christopher Beh
- Lorena Braid
- Fiona S.L. Brinkman
- Mark Brockman
- Jack Chen
- Jonathan Choy
- Lisa Craig
- Sharon Gorski
- Nicholas Harden
- Nancy Hawkins
- Robert Holt
- William Hsiao
- Valentin Jaumouillé
- Dustin King
- Irina Kovalyova
- Mani Larijani
- Amy Lee
- Michel Leroux
- Ryan Morin
- Ingrid Northwood
- Mark Paetzel
- Frederic Pio
- Lynne Quarmby
- Sophie Sneddon
- Jenifer Thewalt
- Glen Tibbits
- Peter Unrau
- Esther Verheyen
- Stephanie Vlachos
- David Vocadlo
- Edgar Young
- Emeritus Faculty
- Associate Members
- Adjunct Faculty
- Research Personnel
- Graduate & Postdocs
- Staff
- Department Committees
- Faculty
- Undergraduate
- Prospective Students
- Current Students
- Advising
- Courses
- Course Offerings
- Summer (1234)
- Spring (1231)
- Fall (1227)
- Summer (1224)
- Spring (1221)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Course Descriptions
- Course Offerings
- Degree Programs
- MBB Co-op Program
- Research Opportunities
- Scholarship & Funding
- Student Resources
- Graduate
- Prospective Students
- Current Students
- Manage Your Program
- Courses
- Course Descriptions
- Course Offerings
- Spring (1231)
- Summer (1234)
- Spring (1221)
- Summer (1224)
- Fall (1227)
- Fall (1217)
- Summer (1214)
- Spring (1211)
- Fall (1207)
- Summer (1204)
- Spring (1201)
- Fall (1197)
- Summer (1194)
- Spring (1191)
- Fall (1187)
- Summer (1184)
- Spring (1181)
- Fall (1177)
- Summer (1174)
- Spring (1171)
- Fall (1167)
- Summer (1164)
- Spring (1161)
- Fall (1157)
- Summer (1154)
- Spring (1151)
- Forms And Resources
- Events
- Graduate Student Caucus
- Research
- Research Labs
- Audas Lab
- Beh Lab
- Braid lab
- Brinkman Lab
- Brockman Lab
- Chen Lab
- Choy Lab
- Craig lab
- Gorski Lab
- Harden Lab
- Hawkins Lab
- Holt Lab
- Hsiao lab
- Jaumouillé lab
- King Lab
- Larijani Lab
- Lee Lab
- Leroux Lab
- Morin Lab
- Paetzel Lab
- Pio Lab
- Quarmby Lab
- Sen Lab
- Thewalt Lab
- Tibbits Lab
- Unrau Lab
- Verheyen Lab
- Vocadlo Lab
- Young lab
- Undergraduate Research Opportunities
- C2D2 Centre for Cell Biology, Development, and Disease
- Omics Data Science Initiative
- Research Labs
- Resources
- News & Events
- MBB Calendar
- Colloquia
- Honours & Awards
- News Archives
- 2023
- Congratulations to Dustin King, Amy Lee and David Vocadlo: recipients of New Frontiers in Research Fund
- SFU research aids fight against treatment-resistant superbugs
- Leroux lab Nature Communications paper identifies novel human disease gene linked to retinal degeneration, one of a growing number of genes associated with ciliary dysfunction (ciliopathies)
- Graduate student Minh Nguyen and his colleagues in the Craig lab reveal the mechanism of Type IV-pilus mediated bacterial secretion
- Global News BC: Dr. Fiona Brinkman Discusses How Scientists Track Mutations in the New Covid-19 Variants
- 2022
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
- Congratulations to our June 2022 Graduands
- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
- Congratulations to our May 2022 Graduands
- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
- A New Paper from Beh Lab on ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways has been published in Plos Genetics Journal
- Dr. Lorena Braid is featured among new and renewed Canada Research Chairs
- 2021
- 2020
- 2019
- 2018
- 2017
- 2016
- 2015
- 2023
- Support
- Faculty + Staff Portal
Chen Lab
My laboratory is interested in developing bioinformatics programs and genomics (and molecular) tools for understanding genome architecture and expression.
In particular, we are interested in characterizing gene structures, transcription factors and regulatory elements, sequence and structural variations, and, more importantly, regulatory mechanisms. Ultimately, we are interested in understanding how genome sequences and their organization (including various modifications) direct development and biological functions. Currently, we primarily use the nematode Caenorhabditis elegans as a model system. Bioinformatics programs and genomics tools, however, are generally readily applicable in all organisms, ranging from bacteria to humans. Current research projects fall into two major categories: (1) Identification and characterization of novel genes, synteny blocks, functional elements, genome variations and genome rearrangements; (2) Transcriptional regulation of genes and gene batteries.
For more details, visit our research lab website.
Selected Publications
- Song H, Chen Y, Liu F, Chen N (2021) Large Differences in the Haptophyte Phaeocystis globosa Mitochondrial Genomes Driven by Repeat Amplifications. Front. Microbiol. 12:676447. doi: 10.3389/fmicb.2021.676447.
- Zongmei C, Qing X, Kate G, Shuya L, Chen N (2021) Metabarcoding analysis of harmful algal bloomspecies in the Changjiang Estuary, China. Science of the Total Environment 782 (2021) 146823. doi: org/10.1016/j.scitotenv.2021.146823.
- Liu S, Gibson K, Cui Z, Chen Y, Sun X, Chen N (2020). Harmful Algae 92 (2020) 101772. doi: org/10.1016/j.hal.2020.101772.
- Gong G, Dan C, Xiao S, Guo W, Huang P, Xiong Y, Wu J, He Y, Zhang J, Li X, Chen N, Gui JF, Mei J. Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis. Gigascience. 2018 Nov 1;7(11). doi: 10.1093/gigascience/giy120.
- Xu S, Xiao S, Zhu S, Zeng X, Luo J, Liu J, Gao T, Chen N. A. draft genome assembly of the Chinese sillago (Sillago sinica), the first reference genome for Sillaginidae fishes. Gigascience. 2018 Sep 1;7(9). doi: 10.1093/gigascience/giy108.
- Qin Z, Johnsen R, Yu S, Chu JS, Baillie DL, Chen N. Genomic Identification and Functional Characterization of Essential Genes in Caenorhabditis elegans. G3 (Bethesda). 2018 Mar 2;8(3):981-997. doi: 10.1534/g3.117.300338.