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- Congratulations to Dr. Amy Lee: The Recipient of The Banting Research Foundation's 2022 Discovery Award
- Meet Our Newest Faculty: Dr. Dustin King on His Exploration of Weaving Western Science with Indigenous Ways of Knowing
- MBB Alumnus Profile: Meet Cory Macklin Who Overcame Challenges to Win Governor General's Silver Medal
- MBB Alumnus Profile: Meet Dr. Razvan Cojocaru, The Recipient of Governor General’s Gold Medal
- Congratulations to Dr. Razvan Cojocaru and Cory Macklin: Governor General Medal Recipients at Summer 2022 Convocation
- Congratulations to our June 2022 Graduands
- Dr. Lynne Quarmby and Her Book "WaterMelon Snow: Science, Art, and a Lone Polar Bear" is Featured in SFU Knowledge Mobilizers Series
- Congratulations to our May 2022 Graduands
- Congratulations to Dr. Mani Larijani for Being Awarded a Prestigious New Frontiers in Research Fund Grant
- A New Paper from Beh Lab on ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways has been published in Plos Genetics Journal
- Congratulations to Dr. Razvan Cojocaru, the recipient of Dr. Bruce Brandhorst Prizes for Best Publication and Best PhD Thesis
- Dr. Lorena Braid is featured among new and renewed Canada Research Chairs
- Learn more about Dr. King's new lab that focuses on natural ‘carbon capture’ solutions
- $2 Million Gift From SFU Professors Emeriti Helps Seed New Ideas at SFU Science
- Congratulations to Dr. Tim Audas on The Renewal of Tier 2 Canada Research Chair in Cellular Stress
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Tibbits Lab
Our research focuses on understanding the mechanisms of inherited cardiomyopathies and arrythmias. The SFU-based lab in TASC II focuses on the use of zebrafish and human recombinant protein structures that make up the thin filament of the cardiac contractile apparatus.
Our lab at BC Children’s Hospital Research Institute (BCCHRI) is part of the Cellular and Regenerative Centre (CRMC) and focuses entirely on the use of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to address these inherited diseases. The attached figure shows the hiPSC-CM pipeline at BCCHRI in which we can start from patient derived Peripheral Blood Mononuclear Cells (PBMC) extracted from a small blood sample or well curated hiPSC lines in the lab. After genome editing and Q/C, the hiPSCs are differentiated into beating cardiomyocytes and then matured in vitro. We can make 2D monolayers of the hiPSC-CMs or use 3D bioprinting technology to make engineered heart tissue. These cells/tissues are then phenotyped in detail using transcriptomic (ddPCR, Nanostring, or RNAseq using Nanopore technology), proteomic (MS), imaging (EM, Cell Painting), and functional (optical mapping, patch clamping) techniques.