Brinkman Lab

Microbe-loving bioinformatics and genomics research lab, aiming to better control infectious diseases and associated immune disorders in a sustainable way.

Infectious disease control needs to be made more “sustainable”. We need to reduce selective pressure on pathogens to evolve antibiotic resistance. We need to control infectious disease outbreaks and associated immune disorders with a better understanding of the genetic, environmental and social factors that impact disease spread and severity.

The Brinkman laboratory is developing bioinformatics methods, and capitalizing on combined bioinformatics and wet-lab approaches, investigating microbes and their host/environmental interactions, to better understand key themes in infectious disease etiology, microbiome conservation, and associated immune disorders. The overall goal is to develop more sustainable, integrated approaches for disease control.

For more details, visit our research lab website.




SSB 7165
SSB 7121


(778) 782-4206

Selected Publications

  • Almblad H, Randall TE, Liu F, Leblanc K, Groves RA, Kittichotirat W, Winsor GL, Fournier N, Au E, Groizeleau J, Rich JD, Lou Y, Granton E, Jennings LK, Singletary LA, Winstone TML, Good NM, Bumgarner RE, Hynes MF, Singh M, Stietz MS, Brinkman FSL, Kumar A, Brassinga AKC, Parsek MR, Tseng BS, Lewis IA, Yipp BG, MacCallum JL, Harrison JJ (2021). Bacterial cyclic diguanylate signaling networks sense temperature. Nature Communications 2021 Mar 31;12(1):1986.
  •  Lau WYV, Hoad GR, Jin V, Winsor GL, Madyan A, Gray KL, Laird MR, Lo R, Brinkman FSL (2021). PSORTdb 4.0: expanded and redesigned bacterial and archaeal protein subcellular localization database incorporating new secondary localizations. Nucleic Acids Res. 2021 Jan 8;49(D1):D803-D808.
  • Maguire F*, Jia B*, Gray KL, Lau WYV, Beiko RG, Brinkman FSL (2020). Metagenome-assembled genome binning methods with short reads disproportionately fail for plasmids and genomic islands. Microb Genom. 2020 Oct 1. doi: 10.1099/mgen.0.000436.  *These authors contributed equally.
  • Patrick DM, Sbihi H, Dai DLY, Al Mamun A, Rasali D, Rose C, Marra F, Boutin RCT, Petersen C, Stiemsma LT, Winsor GL, Brinkman FSL, Kozyrskyj AL, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, Finlay BB, Turvey SE (2020). Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies. The Lancet Respir Med. 2020 Mar 24:S2213-2600(20)30052-7.
  • McDaniel CT, Panmanee W, Winsor GL, Gill E, Bertelli C, Schurr MJ, Dongare P, Paul AT, Ko SB, Lau GW, Dasgupta N, Bogue AL, Miller WE, Mortensen JE, Haslam DB, Dexheimer P, Muruve DA, Aronow BJ, Forbes MDE, Danilczuk M, Brinkman FSL, Hancock REW, Meyer TJ, Hassett DJ (2020). AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4921-4930.
  • Alcock BP, Raphenya AR, Lau TTY, Tsang KK, Bouchard M, Edalatmand A, Huynh W, Nguyen AV, Cheng AA, Liu S, Min SY, Miroshnichenko A, Tran HK, Werfalli RE, Nasir JA, Oloni M, Speicher DJ, Florescu A, Singh B, Faltyn M, Hernandez- Koutoucheva A, Sharma AN, Bordeleau E, Pawlowski AC, Zubyk HL, Dooley D, Griffiths E, Maguire F, Winsor GL, Beiko RG, Brinkman FSL, Hsiao WWL, Domselaar GV, McArthur AG (2020). CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database. Nucleic Acids Res. 2020 Jan 8;48(D1):D517-D525. doi: 10.1093/nar/gkz935.
  • Bertelli C, Tilley KE, Brinkman FSL (2018). Microbial genomic island discovery, visualization and analysis. Brief Bioinform. doi: 10.1093/bib/bby042.

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